Direct interaction between SNAP-23 and L-type Ca2+channel
نویسندگان
چکیده
منابع مشابه
Direct interaction of otoferlin with syntaxin 1A, SNAP-25, and the L-type voltage-gated calcium channel Cav1.3.
The molecular mechanisms underlying synaptic exocytosis in the hair cell, the auditory and vestibular receptor cell, are not well understood. Otoferlin, a C2 domain-containing Ca2+-binding protein, has been implicated as having a role in vesicular release. Mutations in the OTOF gene cause nonsyndromic deafness in humans, and OTOF knock-out mice are deaf. In the present study, we generated otofe...
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چکیده ندارد.
Targeting of SNAP-23 and SNAP-25 in polarized epithelial cells.
SNAP-23 is the ubiquitously expressed homologue of the neuronal SNAP-25, which functions in synaptic vesicle fusion. We have investigated the subcellular localization of SNAP-23 in polarized epithelial cells. In hepatocyte-derived HepG2 cells and in Madin-Darby canine kidney (MDCK) cells, the majority of SNAP-23 was present at both the basolateral and apical plasma membrane domains with little ...
متن کاملDifferential Control of the Releasable Vesicle Pools by SNAP-25 Splice Variants and SNAP-23
The SNARE complex, consisting of synaptobrevin, syntaxin, and SNAP-25, is essential for calcium-triggered exocytosis in neurosecretory cells. Little is known, however, about how developmentally regulated isoforms and other cognate SNARE components regulate vesicular fusion. To address this question, we examined neuroexocytosis from chromaffin cells of Snap25 null mice rescued by the two splice ...
متن کاملInteraction between cannabinoid receptors and inhibition of L-type calcium channel on passive avoidance learning and memory in male rats
Introduction: There is currently a debate over the interaction between Ca2+ channels and cannabinoid system on learning and memory processing. In this study, we examined the effect of acute injection of cannabinoid agonist (Win- 55212-2) (Win) or antagonist (AM251), following chronic injection of verapamil, as a L-type Ca2+ channels blocker, on passive avoidance (PA) test in male Wistar rats...
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ژورنال
عنوان ژورنال: Journal of Cellular and Molecular Medicine
سال: 2005
ISSN: 1582-1838,1582-4934
DOI: 10.1111/j.1582-4934.2005.tb00363.x